Animal Intake Study Scorecards

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High Quality Studies
Study	Score	Carbs	Fats	Protein
Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age	5.0	70% 70%	8% 8%	12% 12%
High saturated fat and low carbohydrate diet decreases lifespan independent of body weight in mice	4.8	60% 15%	15% 60%	25% 25%
Linoleate-Rich High-Fat Diet Decreases Mortality in Hypertensive Heart Failure Rats Compared With Lard and Low-Fat Diets	4.2	44% 44%	42% 42%	14% 14%
Fair Quality Studies
Study	Score	Carbs	Fats	Protein
Fructose decreases physical activity and increases body fat without affecting hippocampal neurogenesis and learning relative to an isocaloric glucose diet	3.8	62% 62%	18% 18%	19% 19%
Metabolic Evidence for Adaptation to a High Protein Diet in Rats	3.8	76% 38%	9% 9%	15% 52%
A Low Carbohydrate, High Protein Diet Slows Tumor Growth and Prevents Cancer Initiation	3.6	55% 16%	22% 26%	23% 58%
Heterogeneous metabolic adaptation of C57BL/6J mice to high-fat diet	3.4	60% <1%	12% 72%	28% 28%
Poor Quality Studies
Study	Score	Carbs	Fats	Protein
Diet-induced type II diabetes in C57BL/6J mice	2.8	63% 27%	11% 36%	26% 15%
Differential effects of saturated versus unsaturated dietary fatty acids on weight gain and myocellular lipid profiles in mice	2.8	70% 35%	10% 45%	20% 20%
Defining high-fat-diet rat models: metabolic and molecular effects of different fat types	2.8	65% 36%	11% 45%	24% 19%
Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent	2.6	58% 37%	18% 45%	24% 18%
A high-fat, ketogenic diet induces a unique metabolic state in mice	2.4	57% 2%	17% 93%	27% 5%
Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice	2.2	72% <1%	8% 72%	19% 28%
Studies not publicly available for review.
Glucose homeostasis in a carnivorous animal (cat) and in rats fed a high-protein diet
High-fat diet-induced hyperglycemia and obesity in mice: Differential effects of dietary oils
Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

Star Calculation

One Constant Macro	0%-2%=>5, 2%-4%=>4, 4%-6%=>3, 6%-8%=>2, >8%=>1
Number of animals per diet	Round(Number of animals per diet / 5 + 1)
Length of Study	Round(Number of Days / 200 + 1)