Study Review: A high-fat, ketogenic diet induces a unique metabolic state in mice

Study: http://www.physiology.org/doi/pdf/10.1152/ajpendo.00717.2006

Energy Macro Percent Usage

Diet	Carbs	Fats	Protein
Standard Chow (LabDiet 5008)	56.5%	16.97%	26.53%
High Fat (D12451)	35%	45%	20%
Ketogenic (F3666)	1.8%	93.4%	4.7%

Historical charts show Keto diet seems to have same weight as calorie restriction even though Keto calorie consumption was similar to normal diet.

One Constant Macro	*	Protein changes by >10%
Constant Nutrients + Fiber	*	Completely different vitamins and minerals. Diets were from different vendors.
Number of animals per diet	***	8 animals per diet
Length of Study	**	Over 120 days.
Funding Bias	*****	Grants by National Institute of Diabetes and Digestive and Kidney Diseases, and by Takeda pharmaceuticals.
Total	2.4	Poor Quality Study